Uniform intratumoral distribution of radioactivity produced using two different radioagents, 64Cu-cyclam-RAFT-c(-RGDfK-)4 and 64Cu-ATSM, improves therapeutic efficacy in a small animal tumor model
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چکیده
منابع مشابه
αVβ3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4.
The transmembrane cell adhesion receptor αVβ3 integrin (αVβ3) has been identified as an important molecular target for cancer imaging and therapy. We have developed a tetrameric cyclic RGD (Arg-Gly-Asp) peptide-based radiotracer (64)Cu-cyclam-RAFT-c(-RGDfK-)4, which successfully captured αVβ3-positive tumors and angiogenesis by PET. Here, we subsequently evaluated its therapeutic potential and ...
متن کاملEvaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model.
UNLABELLED We have evaluated Cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM), an effective marker for the delineation of hypoxic but viable tissue, in vitro in the EMT6 carcinoma cell line under varying degrees of hypoxia and compared it with the flow tracer 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) and the hypoxic tracer 18F-fluoromisonidazole (MISO). We have also comp...
متن کامل64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
BACKGROUND The aim of this study was to compare (64)Cu-diacetyl-bis(N(4)-methylsemicarbazone) ((64)Cu-ATSM) and (18)FDG PET uptake characteristics and (64)Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous canine sarcomas and carcinomas. METHODS Biopsies were collected from individual tumors between approximately 3 and 25 hours after the intravenous injection of (64)C...
متن کاملPET/MR imaging of hypoxic atherosclerosis using 64Cu-ATSM in a rabbit model
ATSM in a rabbit model Xingyu Nie1, 2, Richard Laforest1, Andrew Elvington3, Gwendalyn J. Randolph3, Jie Zheng1, Tom Voller1, Dana R. Abendschein3,4, Suzanne E. Lapi1, 2, 3, Pamela K. Woodard1, 2, 5 Affiliations 1. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA 2. Department of Biomedical Engineering, Washington University in St. Louis, MO, USA...
متن کاملCardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM.
UNLABELLED Myocardial hypoxia is an attractive target for diagnostic and prognostic imaging, but current approaches are insufficiently sensitive for clinical use. The PET tracer copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) ((64)Cu-ATSM) has promise, but its selectivity and sensitivity could be improved by structural modification. We have therefore evaluated a range of (64)Cu-ATSM analogs...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2018
ISSN: 2191-219X
DOI: 10.1186/s13550-018-0407-3